Detroit Lions Week 1 Odds: 49ers Are Sunday’s Biggest NFL Favorites On Slate

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Written By Danny Lawhon on May 12, 2021Last Updated on September 11, 2021
Detroit Lions Week 1 Spread May 2021

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We are now entering the era of Dan Campbell.

This Sunday at Ford Field, the Detroit Lions football team will be under the guidance of their new coach as they face the San Francisco 49ers at 1 p.m. The game will be broadcasted on FOX.

Campbell and the young Lions are not favored by oddsmakers this season, and the perfect proof of this is seen in the opener.

The Lions initially held the title of the largest underdog for Week 1, but Dallas took over that position on Sunday night. However, as of Saturday afternoon, the Lions have reclaimed their position as the projected biggest loser.

2021 Detroit Lions Week 1 Lines (Updated)

The initial spread lines for the Lions’ Week 1 game at Michigan sportsbooks were set at a high point and rapidly increased. However, they have now settled at 7.5 points at one operator. Nevertheless, following the announcement of Lions’ left tackle Taylor Decker’s absence due to a finger injury, the Lions became underdogs by 8 points at certain locations, and as much as 9.5 points at others.

BetMGM Sportsbook was the first to release odds for the September 12th FOX kickoff at 1 p.m. ET, setting San Francisco as a 7-point favorite. Typically, home-field advantage is valued at around 3 or 3.5 points, indicating that the oddsmakers anticipate this game to be a double-digit affair in a neutral setting.

Once DraftKings, FanDuel, and PointsBet joined in, the line had already increased to 7.5 points. This number has remained the early consensus line and marked the most imbalanced in all of the NFL’s Week 1 games.

The Week 1 odds for the Lions-49ers game can be found below, with the opening point total set at 46.

San Francisco 49ers at Detroit Lions Week 1 NFL Odds

Dallas, considered the ultimate underdog in Week 1, was given a +9 point advantage by most bookmakers against Tampa Bay in the NFL opener on Thursday. However, they managed to exceed expectations by covering the spread despite losing 31-29.

Lions vs. 49ers a rough first assignment for Detroit

The Lions’ Week 1 assignment is not favorable, and their new starter, Goff, who previously played as the quarterback for the Los Angeles Rams, is well aware of the challenge.

Coach Kyle Shanahan and quarterback Jimmy Garropolo had quite the departure from their Super Bowl XLIV appearance two seasons ago. After a injury-riddled, last-place finish in the NFC West with a 6-10 record in 2020, the 49ers traded up to the No. 3 pick in this season’s NFL Draft.

Most sportsbooks predict that the 49ers will achieve around 10.5 victories during the regular season, while the Lions are expected to have one of the lowest win totals in the league, ranging from 5 to 5.5.

With the Lions entering a new era under Campbell and general manager Brad Holmes, it’s understandable why the 49ers are favored as their opening opponent.

Decker injury could hamper Lions’ offense in opener

Kevin Bastin, who resigned in 2019, has been rehired as the head athletic trainer on Wednesday. He already has a lot on his plate.

Decker (finger) has been ruled out for Sunday’s game by the Lions. Additionally, the game-time availability of defensive end Michael Brockers, defensive end Levi Onwuzurike, cornerback A.J. Parker, and defensive end Nick Williams remains uncertain as they are listed as questionable.

This week, the Lions announced their captains as Goff, center Frank Ragnow, linebackers Trey Flowers and Alex Anzalone, and Jalen Reeves-Maybin (special teams) take charge.

One concern facing the Lions this season revolves around the limited number of effective choices in their wide receiver position. However, there is hope that Tyrell Williams could potentially fill the role of the team’s top receiver, given his impressive track record. Since 2015, Williams has recorded the highest number of touchdown receptions of 75 yards or more in the NFL, tying him with notable players such as Tyreek Hill, Odell Beckham Jr., DeSean Jackson, and JuJu Smith-Schuster.

T.J. Hockenson vs. George Kittle in battle of top tight ends

If you’re in search of props related to the Lions, consider keeping an eye on tight end T.J. Hockenson. He will be aiming to outperform his friend and fellow Iowa product, George Kittle, who is a Pro Bowler.

As Hockenson embarks on his third year, he proudly boasts a remarkable achievement of scoring touchdowns in both of his initial Week 1 performances. Remarkably, he has become the pioneering tight end in NFL history to accomplish this feat, having not only scored a touchdown but also gained 50 yards or more in each of his first two Week 1 appearances.

Despite missing half of last season due to a broken foot, Kittle was able to achieve over 1,000 receiving yards and 80 catches in both of the two preceding seasons.

NFL Week 1 odds at Michigan sportsbooks

Other 2021 Detroit Lions NFL Game Odds

DraftKings, along with other outlets, has provided early lookahead spreads and moneylines for certain games throughout the season. Let’s take a look at what Detroit has to offer.

Lions 2021 Week 2 Odds

The Detroit Lions face a tough challenge in Week 2 as they hit the road for their first away game of the season against the Green Bay Packers at Lambeau Field. On September 19, for a Monday night game, the Lions were initially considered 10-point underdogs. See the latest odds below.

Lions 2021 Week 3 Odds

On September 26, the Lions will face Lamar Jackson and the Baltimore Ravens, assuming the role of 7.5-point underdogs at their home stadium. Please find the latest odds provided below.

Lions 2021 Week 4 Odds

On October 3rd, Detroit will be heading to face the Chicago Bears as the underdogs with a 5.5-point disadvantage.

Lions 2021 Week 5 Odds

Currently off the board at DraftKings, the Lions are set to face the Minnesota Vikings on October 10th for their second consecutive NFC North road game.

Lions 2021 Week 6 Odds

Oddsmakers have given the Detroit Lions a viable opportunity to win their Week 6 matchup against the Cincinnati Bengals, which will take place on October 17th. Despite facing Joe Burrow and his team, the Lions are merely considered a 1-point underdog.

Lions 2021 Week 7 Odds

The Goff-Stafford game mentioned earlier is scheduled to occur in Los Angeles during Week 7 on October 24th. In this matchup, the Lions face the challenge of being a 10.5-point underdog, resulting in even greater odds against them. The moneyline reflects this with the Lions being listed at +420.

Lions 2021 Week 12 Odds

The annual Thanksgiving affair sees Detroit hosting NFC North rival Chicago on Nov. 25. The Lions are only 4.5-point underdogs in this one, with a +170 rate on the moneyline.

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